Sarah Naomi Bolz

The paper benchmarks a new substitution matrix derived from AlphaFold-predicted structures against existing matrices, finding similar performance and highlighting the diminishing role of substitution matrices with more sequence data.

The paper uses PLIP to analyze structural data of drug-target interactions, revealing insights into the design principles of drugs targeting protein-protein interactions.

The paper evaluates drug repositioning approaches by analyzing 100 drugs, 200 targets, and 300 indications, finding that disease and target-centric methods dominate over drug-centric ones.