The S1PR modulator Ozanimod reverses spine deficits, Amyloid-β plaques deposition and neuroinflammation in aged APP/PS1 mice
Rieke Fritz, Thomas Endres, Lukas Schoenwolf, Georgia-Ioanna Kartalou, Kurt Gottmann, Volkmar Leßmann
This study shows that Ozanimod treatment reduces synaptic deficits, amyloid-β plaques, and neuroinflammation in aged APP/PS1 mice.
bioRxiv · May 6, 2026 · PreprintNeuroscience