Volkmar Leßmann

Ferulic acid eicosyl ester enhances cognitive flexibility and modulates arousal-related neural circuits in mice

This study shows that FAE-20 improves cognitive flexibility in young adult mice but not spatial learning, with sex-specific effects on arousal-related neural circuits.

The S1PR modulator Ozanimod reverses spine deficits, Amyloid-β plaques deposition and neuroinflammation in aged APP/PS1 mice

This study shows that Ozanimod treatment reduces synaptic deficits, amyloid-β plaques, and neuroinflammation in aged APP/PS1 mice.

Calcium-permeable AMPA receptors mediate timing-dependent LTP elicited by low repeat coincident pre- and postsynaptic activity at Schaffer collateral-CA1 synapses

The paper shows that low repeat STDP stimulation can induce robust t-LTP through different mechanisms depending on the postsynaptic AP pattern and receptor involvement.

Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model

This study shows that FTY720 treatment after symptom onset in an AD mouse model improves synaptic and memory deficits through anti-inflammatory effects.