Active and Passive Mechanical Deficits Precede Spinal Curvature in a Zebrafish Model of Idiopathic Scoliosis
Johnathan R. O’Hara-Smith, S. Bertrand, Julissa Ortiz-Delatorre, Rachael M. Giersch, Luke A Rethwill, Damien M. Callahan, Daniel T. Grimes
The paper identifies biomechanical deficits in zebrafish mutants that precede spinal curvature, linking urotensin signaling to axial tissue mechanics in scoliosis.
bioRxiv · May 3, 2026 · PreprintDevelopmental Biology