Johnathan R. O’Hara-Smith

This study develops affibody-conjugated hydrogels to phase the delivery of VEGF, FGF-2, and PDGF, enhancing in vitro angiogenesis by 2.8-fold in vascular network length and 4.1-fold in branching.

The paper identifies biomechanical deficits in zebrafish mutants that precede spinal curvature, linking urotensin signaling to axial tissue mechanics in scoliosis.

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

This study identifies Urp1 and Urp2 as essential for zebrafish spine morphology, showing their role in preventing lordosis-like curves and establishing new models for spinal curvature disorders.