Daniel T. Grimes

This study shows that serotonergic signaling is critical for spinal stability in zebrafish, with tph2 mutants exhibiting spinal curvature due to neuronal defects before visible curvature appears.

The paper identifies biomechanical deficits in zebrafish mutants that precede spinal curvature, linking urotensin signaling to axial tissue mechanics in scoliosis.

The paper shows that motile cilia remodel Sspo into a tensioned Reissner fiber anchored to the floor plate, linking ciliary activity to body morphogenesis.

A novel Cfap298 mutation disrupts left-right patterning in mice by impairing ciliary motility, revealing a conserved protein region essential for this function across species.

This study shows that TAT1 is essential for touch sensation in zebrafish but not for embryonic development or ciliary function.

This study identifies Urp1 and Urp2 as essential for zebrafish spine morphology, showing their role in preventing lordosis-like curves and establishing new models for spinal curvature disorders.

This study identifies ZIP-5/bZIP transcription factor regulation of folate metabolism as critical for aging axon regeneration, showing dietary folic acid improves regeneration in C. elegans and zebrafish.