FICD acts bi-functionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP
Steffen Preissler, Claudia Rato, Luke Perera, Vladimir Saudek, David Ron
This paper identifies FICD as the enzyme that both AMPylates and de-AMPylates BiP, revealing its dual functionality in regulating ER chaperone activity in response to stress.
Nature Structural & Molecular Biology · Dec 5, 2016Peer-reviewedBiochemistry