Author
Broad Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Dylan M. Cable, Evan M. Murray, Vignesh Shanmugam, Simon Zhang, Luli S. Zou, Michael Diao, Haiqi Chen, Evan Z. Macosko, Rafael A. Irizarry, Fei Chen
The paper introduces a statistical method to detect cell type-specific differential gene expression in spatial transcriptomics data and validates it using simulations and real datasets.
Nature Methods · Sep 1, 2022Peer-reviewedGenomics
Luli S. Zou, Tongtong Zhao, Dylan M. Cable, Evan M. Murray, Martin J. Aryee, Fei Chen, Rafael A. Irizarry
The paper introduces spASE, a method to detect spatial patterns in allele-specific expression from spatial transcriptomics data, showing it can identify cell type-specific effects in mouse hippocampus.
bioRxiv · Dec 1, 2021 · PreprintGenomics
Dylan M. Cable, Evan M. Murray, Luli S. Zou, Aleksandrina Goeva, Evan Z. Macosko, Fei Chen, Rafael A. Irizarry
This paper introduces RCTD, a method to decompose cell type mixtures in spatial transcriptomics, improving cell type assignment and enabling discovery of spatially dependent gene expression.
Nature Biotechnology · Feb 18, 2021Peer-reviewedGenomics
Vivek Rai, Daniel X. Quang, Michael R. Erdos, Darren A. Cusanovich, Riza M. Daza, Narisu Narisu, Luli S. Zou, John P. Didion, Yuanfang Guan, Jay Shendure, Stephen C.J. Parker, Francis S. Collins
The paper uses single-cell ATAC-seq and deep learning to analyze pancreatic islet cells, revealing cell-specific regulatory signatures linked to type 2 diabetes.
Molecular Metabolism · Dec 20, 2019Peer-reviewedGenomics
Luli S. Zou, Michael R. Erdos, D. Leland Taylor, Peter S. Chines, Arushi Varshney, Stephen C.J. Parker, Francis S. Collins, John P. Didion
BoostMe improves DNA methylation imputation in WGBS data, enhancing concordance with the MethylationEPIC array and identifying tissue-specific regulatory features.
BMC Genomics · May 23, 2018Peer-reviewedGenomics