Haiqi Chen

This study shows that extrachromosomal circular DNA (eccDNA) in the male germline can integrate into the genome and contribute to structural variations, with diabetes increasing eccDNA levels in sperm.

ECHOS enables spatial epigenome profiling at subcellular resolution by combining high-resolution imaging and high-throughput sequencing, revealing distinct gene regulatory logics and epigenetic changes in human tissues.

The paper identifies rare SIRT6 variants in centenarians that increase protein levels and delay cellular senescence, offering insights for geroprotective therapies.

PHOTON captures subcellular RNA localization using imaging and sequencing, revealing m6A's role in stress granule mRNA partitioning.

The paper develops a tool for continuous, long-range, targeted diversification of endogenous mammalian genomes and uses it to explore the function of genetic variants in both coding and non-coding regions.

This study identifies eccDNA in human male germline and links its abundance to chronic diseases through transcriptional activity and apoptosis signaling.

The paper introduces Photoselective Sequencing, a method to measure genomic data with subcellular resolution, and applies it to study chromatin accessibility and nuclear positioning in mouse brain cells.

The paper introduces a statistical method to detect cell type-specific differential gene expression in spatial transcriptomics data and validates it using simulations and real datasets.

This study uses Slide-seqV2 to identify disease-specific cell neighborhoods and pathways in human and mouse kidneys.

This study uses spatial transcriptomics to create a spatial atlas of testis gene expression, identifying spatially segregated spermatogonial populations and disruptions in diabetic testes.