Tumor context determines ARID1A effects on gastric cancer immunity
Shu Xiao, Ryan T. Heslin, Morgan F. Pettigrew, John D. Karalis, Nafeesah Fatimah, Shao-Po Huang, Verena Cao, Esther Burns, Lynn Y. Kwon, Ibrahim Nassour, Skylar L. Nahi, Hsien‐Tsung Lai, Changjin Hong, Tae Hyun Hwang, Isaac S. Chan, , Sam C. Wang
This study shows that ARID1A loss in gastric cancer affects immune evasion depending on tumor context, with different outcomes in mouse models and human subtypes.
bioRxiv · Aug 22, 2026 · PreprintCancer Biology