Elevated Expression of MALAT1 Contributes to the Survival of Drug-Tolerant Persister Cells Following Targeted Therapy in Lung Adenocarcinoma
William J. H. Davis, M Thompson, Safia M Farry, Cushla McKinney, Grégory Gimenez, Mark E. Hatley, Rajiv Kumar, Euan James Rodger, Aniruddha Chatterjee, Sarah D. Diermeier, Catherine J. Drummond, Glen Reid
This study identifies MALAT1 as a key lncRNA supporting drug-tolerant persister cells in lung adenocarcinoma, showing its role in treatment resistance and suggesting it as a potential therapeutic target.
bioRxiv · May 12, 2026 · PreprintCancer Biology