Limited within-host diversity and tight transmission bottlenecks limit SARS-CoV-2 evolution in acutely infected individuals
K. Braun, G. K. Moreno, C. Wagner, M. A. Accola, W. M. Rehrauer, D. A. Baker, K. Koelle, D. O'Connor, T. Bedford, T. Friedrich, L. H. Moncla
The paper analyzes SARS-CoV-2 within-host diversity and transmission bottlenecks in acute infections, finding limited diversity and narrow bottlenecks that restrict variant spread.
bioRxiv · Apr 30, 2021 · PreprintEvolutionary Biology