M. A. Dias Louro

Adaptation of human cell populations to different levels of centriole amplification

This study examines how human cell populations adapt to different levels of centriole amplification through long-term experimental evolution and fitness analysis.

A first-takes-all model of centriole copy number control

The paper proposes a model explaining how cells ensure precise centriole duplication by sequestering building blocks through cartwheel elongation, showing it can produce one centriole copy despite stochasticity.

Patterns of selection against centrosome amplification in human cell lines

The paper infers patterns of centriole overproduction and selection in human cell lines using mutation-selection-like models and finds strong uniform selection against extra centrioles.