The chromatin regulator HMGA1a undergoes phase separation in the nucleus
H. Zhu, M. Narita, J. A. Joseph, G. Krainer, W. E. Arter, I. Olan, K. L. Saar, N. Ermann, J. R. Espinosa, Y. Shen, M. A. Kuri, R. Qi, T. J. Welsh, Y. Xu, R. Collepardo-Guevara, , T. Knowles
This study shows HMGA1a undergoes phase separation in the nucleus, driven by protein-DNA interactions and its disordered C-terminal tail.
bioRxiv · Oct 14, 2021Biophysics