M. Narita

Precise immunofluorescence canceling for highly multiplexed imaging capturing specific cell state

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

Autophagy maintains the homeostatic environment in the male reproductive accessory organs playing a key role in fertility

This study shows that autophagy is essential for maintaining the function of male reproductive accessory organs, and its inhibition leads to subfertility, with recovery upon autophagy restoration.

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

This study shows platinum chemotherapy induces a senescent secretome in lung cancer that promotes tumor growth via the TGFβR1/Akt-mTOR axis, and targeting this pathway reduces tumor burden.

Bioprinting microporous functional living materials from protein-based core-shell microgels

This paper introduces a core-shell microgel bioprinting method to create functional living materials with controlled microporosity and enhanced bioprocessing capabilities.

The chromatin regulator HMGA1a undergoes phase separation in the nucleus

This study shows HMGA1a undergoes phase separation in the nucleus, driven by protein-DNA interactions and its disordered C-terminal tail.

The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency

This study shows that ESRG, a HERV-H-driven lncRNA in human pluripotent stem cells, is not required for maintaining or reprogramming pluripotency.

Senescent cell death as an aging resistance mechanism in naked mole-rat

This study identifies senescent cell death as a mechanism contributing to the aging resistance in naked mole-rats, linking low antioxidant defense with suppressed senescent cell accumulation.

Temporal inhibition of autophagy reveals segmental reversal of aging with increased cancer risk

This study shows that inhibiting autophagy in mammals accelerates aging and increases cancer risk, while restoring autophagy extends lifespan but does not fully prevent cancer.

NOTCH-mediated non-cell autonomous regulation of chromatinstructure during senescence

This study shows NOTCH signaling modulates chromatin structure both autonomously and non-autonomously in senescent cells through the JAG1-NOTCH-HMGA1 axis.