Nelfinavir induces cytotoxicity towards high-grade serous ovarian cancer cells, involving induction of the unfolded protein response, modulation of protein synthesis, DNA damage, lysosomal impairment, and potentiation of toxicity caused by proteasome inhibition
M. R. Subeha, A. A. Goyeneche, P. Bustamante, M. A. Lisio, J. V. Burnier, C. M. Telleria
This study shows nelfinavir induces cytotoxicity in high-grade serous ovarian cancer cells through DNA damage, unfolded protein response, and synergistic effects with proteasome inhibitors.
bioRxiv · Oct 25, 2021Cancer Biology