Non-additive effects of changing the cytochrome P450 ensemble: incorporation of CYP2E1 into human liver microsomes and its impact on CYP1A2
N. Y. Davydova, B. Dangi, M. A. Maldonado, N. E. Vavilov, V. G. Zgoda, D. R. Davydov
This study shows that incorporating CYP2E1 into human liver microsomes alters the metabolism of its substrates and shifts substrate metabolism from CYP2C19 to CYP1A2.
bioRxiv · Jul 10, 2019Biochemistry