Escalating protein supersaturation underlies inclusion formation in muscle proteinopathies
P. Ciryam, M. Antalek, F. C. Samper, G. Tartaglia, C. M. Dobson, A.-K. Guettsches, B. Eggers, M. Vorgerd, K. Marcus, R. Kley, R. Morimoto, M. Vendruscolo, C. C. Weihl
The paper quantifies protein supersaturation in muscle biopsies from PAM patients, showing it escalates near pathological inclusions and correlates with aggregation.
bioRxiv · Sep 12, 2019 · PreprintBiophysics