Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
E. M. Lynch, S. Pittman, J. Daw, C. Ikenaga, S. Chen, D. D. Dhavale, M. E. Jackrel, Y. M. Ayala, P. Kotzbauer, C. V. Ly, A. Pestronk, T. E. Lloyd, C. C. Weihl
This study shows that TDP-43 aggregate seeds persist in both mouse and human skeletal muscle even after the removal of large TDP-43 inclusions.
bioRxiv · Apr 3, 2024Pathology
A. K. Bhadra, M. J. Rau, J. A. Daw, J. A. J. Fitzpatrick, C. C. Weihl, H. True
This study identifies how LGMDD1 mutations in DNAJB6 disrupt chaperone function and shows that modulating NEF can rescue substrate processing defects.
bioRxiv · Dec 22, 2021 · PreprintBiochemistry
R. Ganji, J. Paulo, Y. Xi, I. Kline, J. Zhu, C. S. Clemen, C. C. Weihl, J. G. Purdy, S. Gygi, M. Raman
This study shows that the p97-UBXD8 complex regulates ER-mitochondria contact sites by modulating membrane lipid saturation and composition, with implications for neurodegenerative diseases.
bioRxiv · Dec 8, 2021 · PreprintCell Biology
R. Bengoechea, A. R. Findlay, A. Bhadra, H. Shao, K. Stein, S. K. Pittman, J. Daw, J. Gestwicki, H. True, C. C. Weihl
This study shows that inhibiting DNAJ-HSP70 interaction improves muscle strength in LGMD1D by re-mobilizing HSP70 and correcting myopathology.
bioRxiv · Jan 3, 2020Cell Biology
P. Ciryam, M. Antalek, F. C. Samper, G. Tartaglia, C. M. Dobson, A.-K. Guettsches, B. Eggers, M. Vorgerd, K. Marcus, R. Kley, R. Morimoto, M. Vendruscolo, C. C. Weihl
The paper quantifies protein supersaturation in muscle biopsies from PAM patients, showing it escalates near pathological inclusions and correlates with aggregation.
bioRxiv · Sep 12, 2019 · PreprintBiophysics