Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac function
M. Arici, M. Ferrandi, P. Barassi, S.-C. Hsu, E. Torre, A. Luraghi, C. Ronchi, G.-J. Chang, F. Peri, P. Ferrari, G. Bianchi, M. Rocchetti, A. Zaza
This paper investigates PST3093, a metabolite of istaroxime, showing it selectively stimulates SERCA2a and improves cardiac function in a rat model of diabetic cardiomyopathy.
bioRxiv · Aug 17, 2021Pharmacology & Toxicology