Author

M. Bage

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Biophysics· 1

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Approach:deep learning· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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A. V. Pisliakov· 1 shared J. A. Bueren-Calabuig· 1 shared V. H. Cowling· 1 shared

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2019-2019 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

A. V. Pisliakov

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1 paper

Recent·Most cited

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: Insights from accelerated molecular dynamics simulations

J. A. Bueren-Calabuig, M. Bage, V. H. Cowling, A. V. Pisliakov

This study uses molecular dynamics simulations to reveal how RAM allosterically activates RNMT by stabilizing optimal substrate binding conformations and facilitating cooperative cap and AdoMet binding.

bioRxiv · Mar 3, 2019Biophysics