Author

V. H. Cowling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Galloway· 2 shared A. V. Pisliakov· 2 shared R. Almohammed· 2 shared A. Atrih· 1 shared A. Rojas-Fernandez· 1 shared A. W. McClure· 1 shared B. Canal· 1 shared C. Basier· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

A. Galloway

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Author profile →

6 papers

Recent·Most cited

CMTR1 is recruited to transcription start sites and promotes ribosomal protein and histone gene expression in embryonic stem cells

S. Liang, J. C. Silva, O. Suska, R. Lukoszek, R. Almohammed, V. H. Cowling

This study shows CMTR1 binds to transcription start sites and promotes expression of histone and ribosomal protein genes in embryonic stem cells, with effects on translation and DNA replication stress.

bioRxiv · Feb 1, 2022Cell Biology

Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase

C. Basier, S. Basu, R. Beale, B. Canal, V. H. Cowling, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, C. T. Lim, T. Mak, A. W. McClure, , T. U. Zeisner

This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.

Biochemical Journal · Jul 2, 2021Peer-reviewedBioengineering

Identification of novel RNA Polymerase II CTD interaction sites on the mRNA Capping Enzyme

M. G. Bage, R. Almohammed, V. H. Cowling, A. V. Pisliakov

The paper identifies novel RNA Polymerase II CTD interaction sites on the mRNA Capping Enzyme using computational methods and validates them experimentally, showing conservation across eukaryotic taxa.

bioRxiv · Feb 25, 2020 · PreprintBiophysics

CAP-MAP: Cap Analysis Protocol with Minimal Analyte Processing, a rapid and sensitive approach to analysing mRNA cap structures

A. Galloway, A. Atrih, R. Grzela, E. Darzynkiewicz, M. A. Ferguson, V. H. Cowling

The paper introduces CAP-MAP, a method for detecting mRNA cap structures, and shows it is rapid and sensitive for analyzing cap modifications in mRNA.

bioRxiv · Dec 29, 2019Biochemistry

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: Insights from accelerated molecular dynamics simulations

J. A. Bueren-Calabuig, M. Bage, V. H. Cowling, A. V. Pisliakov

This study uses molecular dynamics simulations to reveal how RAM allosterically activates RNMT by stabilizing optimal substrate binding conformations and facilitating cooperative cap and AdoMet binding.

bioRxiv · Mar 3, 2019Biophysics

DHX15 regulates CMTR1-dependent gene expression and cell proliferation

F. Inesta-Vaquera, A. Galloway, L. Chandler, A. Rojas-Fernandez, V. K. Chaugule, S. Weidlich, M. Peggie, V. H. Cowling

This study identifies DHX15 as a regulator of CMTR1-dependent gene expression and cell proliferation through their interaction and functional interplay in RNA processing.

bioRxiv · Mar 3, 2017Cell Biology