Deciphering colchicine like actions of clerodin in terms of microtubule destabilization based mitotic abnormalities, G2/M-phase arrest, and plant polyploidy
S. Roy, L. M. Kundu, G. C. Roy, M. Barmana, T. Chakrabortya, P. Ghosh, R. Das, D. Tripathy, N. Singh, S. Banerjee, A. Bhattacharjee, A. Pal, A. Chatterjee, S. Ray
This study shows clerodin induces mitotic abnormalities, G2/M arrest, and polyploidy in cells, similar to colchicine, through microtubule destabilization and shared binding site interaction.
bioRxiv · Dec 27, 2020 · PreprintCell Biology