Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer: Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations
A. K. Singh, B. De Wijngaert, M. Bijnens, K. Uyttersprot, H. Nguyen, S. E. Martinez, D. Schols, P. Herdewijn, C. Pannecouque, E. Arnold, K. Das
The paper determines cryo-EM structures of HIV-1 reverse transcriptase with nonnucleoside inhibitors, revealing structural changes due to resistance mutations.
bioRxiv · Feb 27, 2022 · PreprintBiophysics