A. K. Singh

miRNA-mRNA Interaction Network Analysis in Alzheimer's Disease for Biomarker Discovery

The paper identifies AD-associated miRNA-mRNA regulatory signatures and potential biomarkers using transcriptomic data from ADNI and GSE48552.

Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners

This study shows that blocking glucagon signaling increases non-alpha cell proliferation in islets, dependent on SLC7A2 and mTORC1, across multiple species and models.

UPF1 localises to mitochondria and is linked to mitochondrial gene expression and function in Drosophila

This study shows UPF1 localizes to mitochondria in Drosophila and affects mitochondrial gene expression and function independently of its role in NMD.

The Northern Colours: Isolation and Characterisation of 4 Pigment-Producing Bacteria from the Arctic

This study isolates and characterizes four pigment-producing bacteria from Arctic stone samples for potential pharmaceutical and industrial applications.

Nitrogen Management on Improving Resilience of Flood-Tolerant (Sub1) Rice Varieties in Flood-Prone Rainfed Lowlands

This study investigates the effect of nitrogen management on the survival and productivity of flood-tolerant rice varieties, finding that a specific nitrogen application strategy improves submergence tolerance and yield.

Leveraging Soil Mapping and Machine Learning to Improve Spatial Adjustments in Plant Breeding Trials

The paper compares spatial adjustment methods in plant breeding trials, finding that XGBoost improves yield estimates by incorporating soil feature modeling at different scales.

Activated PI3Kδ specifically perturbs mouse Treg homeostasis and function leading to immune dysregulation

This study shows that increased PI3Kδ activity in Tregs disrupts their function and homeostasis, leading to immune dysregulation and autoimmunity in mice.

Dual localization of JA receptor, CaCOI2, explains JA perception dynamics in chickpea

This study identifies CaCOI2 as a functional JA receptor in chickpea and shows its subcellular localization changes upon JA perception, revealing new insights into JA signaling mechanisms.

Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma

This study shows that loss of NgBR/cis-PTase function in the liver leads to fatty liver disease that progresses to hepatocellular carcinoma with 100% penetrance, and DGAT2 inhibition prevents this progression.

A translation proofreader of archaeal origin imparts multialdehyde stress tolerance to land plants

This study shows that the archaeal DTD2 enzyme protects plants from aldehyde toxicity by removing harmful adducts on tRNA, and its overexpression enhances aldehyde resistance in Arabidopsis.

Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma

This study identifies the base excision repair pathway as a regulator of transcription-replication conflicts in pancreatic ductal adenocarcinoma, showing that its inhibition enhances DNA damage and reduces cell proliferation.

Insights into the genomic features, lifestyle and therapeutic potential of B1 sub-cluster mycobacteriophages

This study functionally annotates and experimentally characterizes B1 sub-cluster mycobacteriophages, revealing their genomic features, lifestyle, and therapeutic potential against drug-resistant M. smegmatis.

Mitochondrial calcium signaling mediated transcriptional regulation of keratin filaments is a critical determinant of melanogenesis

This study identifies mitochondrial Ca2+ signaling and keratin filaments as critical regulators of melanogenesis, revealing a feedback loop involving MCU, NFAT2, and keratin 5.

Comparative transcriptome analysis in contrasting finger millet (Eleusine coracana (L.) Gaertn) genotypes for heat stress

This study compares transcriptome responses to heat stress in two finger millet genotypes, identifying differentially expressed genes and pathways associated with heat tolerance.

Using Machine Learning Enabled Phenotyping To Characterize Nodulation In Three Early Vegetative Stages In Soybean

The paper uses machine learning to analyze nodulation patterns in soybean across three growth stages, finding genotypic differences in nodule count, size, and total area, with a strong correlation between early taproot nodules and seed nitrogen content.

Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

This study investigates the binding specificity of PfBDP1 bromodomain to acetylated histones in P. falciparum, revealing its preference for tetra-acetylated H4 and potential therapeutic implications.

The plant nucleoplasmin AtFKBP43 needs its extended arms for histone interaction

The paper identifies that AtFKBP43 requires its C-terminal acidic arms for histone interaction, revealing a new subclass of FKBP nucleoplasmins.

Dynamic single-cell RNA sequencing reveals BCG vaccination curtails SARS-CoV-2 induced disease severity and lung inflammation

This study uses single-cell RNA sequencing to show BCG vaccination reduces SARS-CoV-2 lung inflammation and disease severity by enhancing antibody production and altering immune cell transcriptional profiles.

Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer: Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

The paper determines cryo-EM structures of HIV-1 reverse transcriptase with nonnucleoside inhibitors, revealing structural changes due to resistance mutations.

Outer membrane protein A (OmpA) deficient Salmonella Typhimurium displays enhanced susceptibility towards β-lactam antibiotics: third-generation cephalosporins (ceftazidime) and carbapenems (meropenem)

This study shows that deleting OmpA in Salmonella Typhimurium increases susceptibility to β-lactam antibiotics like ceftazidime and meropenem, leading to bacterial death.

Presence of sodium taurocholate co-transporting polypeptide and Hepatitis B replication marker on placenta: Another home for the virus

The paper investigates NTCP and HBV replication markers in placental cells, finding NTCP expression and viral markers suggesting placental susceptibility to HBV and potential replication.

miRNA mediated downregulation of non-muscle Cyclase associated protein 1 is required for myogenic differentiation

This study shows that miRNA-mediated downregulation of Cap1 is essential for myogenic differentiation by regulating actin dynamics and myoblast fusion.

Multi-layer Regulation of Rubisco in Response to Altered Carbon Status in Synechococcus elongatus PCC 7942

The paper investigates how Rubisco activity and organization respond to changes in carbon availability in Synechococcus elongatus PCC 7942, revealing their role in metabolic balancing.

KMT2D Loss Promotes Head and Neck Squamous Cell Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment

This study shows KMT2D loss in HNSCC leads to enhancer reprogramming and immune microenvironment changes, promoting tumor growth through interferon signaling disruption.

ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection

The paper develops a monoclonal antibody cocktail (ZRC-3308) effective against multiple SARS-CoV-2 variants in Syrian hamsters.

Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - Targeting P-pocket by fragment screening

The paper identifies a transient P-pocket in HIV-1 reverse transcriptase during DNA sliding and demonstrates fragment screening to target this pocket for inhibitor development.

New cellular models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor

This study generates new cell lines for undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor to better study sarcomagenesis and develop therapies.

The Sugar Porter gene family of Piriformospora indica: Nomenclature, Transcript Profiling and Characterization

The paper identifies and characterizes 19 hexose transporters in Piriformospora indica, showing differential expression under various nutrient conditions and functional roles in carbohydrate uptake.

H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis

This study shows that H3K27me3 promotes TNBC peritoneal metastasis by upregulating KRT14 through repression of Sp1, and suggests tazemetostat as a potential therapeutic target.

Immunogenic Potential of DNA Vaccine candidate, ZyCoV-D against SARS-CoV-2 in Animal Models

This study evaluates the immunogenic potential of the DNA vaccine ZyCoV-D against SARS-CoV-2 in animal models, showing antibody and Th-1 responses.