Author

B. De Wijngaert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 3 Approach:experimental assay· 3 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2 Organism:yeast· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

K. Das· 4 shared J. Shen· 2 shared S. E. Martinez· 2 shared S. S. Patel· 2 shared A. Camps· 1 shared A. K. Singh· 1 shared B. Provinciael· 1 shared C. Dharia· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiophysics

K. Das

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural insights into TRAP association with ribosome-Sec61 complex, and translocon inhibition by a CADA derivative

E. Pauwels, N. R. Shewakramani, B. De Wijngaert, A. Camps, B. Provinciael, J. Stroobants, K.-U. Kalies, E. Hartmann, P. Maes, K. Vermeire, K. Das

The paper presents cryo-EM structures of the ribosome-Sec61 complex with TRAP and CK147, showing TRAP's binding and CK147's inhibition mechanism.

bioRxiv · Sep 28, 2022Cell Biology

Yeast mtDNA transcription initiation in single nucleotide addition steps

Q. Goovaerts, J. Shen, B. De Wijngaert, U. Basu, S. S. Patel, K. Das

This study reports cryo-EM structures of yeast mitochondrial RNA polymerase initiation complexes, revealing the stepwise process of transcription initiation and the role of structural changes in RNA synthesis.

bioRxiv · Sep 27, 2022 · PreprintBiochemistry

Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer: Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

A. K. Singh, B. De Wijngaert, M. Bijnens, K. Uyttersprot, H. Nguyen, S. E. Martinez, D. Schols, P. Herdewijn, C. Pannecouque, E. Arnold, K. Das

The paper determines cryo-EM structures of HIV-1 reverse transcriptase with nonnucleoside inhibitors, revealing structural changes due to resistance mutations.

bioRxiv · Feb 27, 2022 · PreprintBiophysics

Cryo-EM structures reveal transcription initiation steps by yeast mitochondrial RNA polymerase

B. De Wijngaert, S. Sultana, C. Dharia, H. Vanbuel, J. Shen, D. vasilchuk, S. E. Martinez, E. Kandiah, S. S. Patel, K. Das

The paper uses cryo-EM to reveal steps of transcription initiation by yeast mitochondrial RNA polymerase, including promoter melting, template alignment, and abortive synthesis mechanisms.

bioRxiv · Apr 13, 2020Biophysics