Invariant chain regulates endosomal fusion and maturation through the SNARE Vti1b
D. Frei, A. Margiotta, M. Borg Distefano, M. Moulefera, L. Janssen, J. Thibodeau, J. Neefjes, O. Bakke
This study identifies Vti1b as a SNARE protein that interacts with invariant chain (Ii) to regulate endosomal fusion and maturation, delaying endosomal maturation for efficient antigen processing.
bioRxiv · Sep 18, 2019 · PreprintCell Biology