The Mammalian Cytosolic Type 2 (R)-β-hydroxybutyrate Dehydrogenase (BDH2) is 4-oxo-L-proline Reductase (EC1.1.1.104)
S. P. Kwiatkowski, M. Bozko, M. Zarod, A. Witecka, A. K. Jagielski, J. Drozak
This paper identifies BDH2 as the enzyme responsible for reducing 4-oxo-L-proline to cis-4-hydroxy-L-proline, challenging the previous belief that it produces trans-4-hydroxy-L-proline.
bioRxiv · Feb 23, 2021 · PreprintBiochemistry