Author

J. Drozak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:protein folding & dynamics· 2 Organism:rat· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. K. Jagielski· 2 shared A. Witecka· 2 shared S. Kwiatkowski· 2 shared A. K. Seliga· 1 shared C. Xu· 1 shared D. Vertommen· 1 shared G. Wu· 1 shared H. Deng· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

A. K. Jagielski

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4 papers

Recent·Most cited

Substrate Specificity for Human Histidine Methyltransferase SETD3

J. Hintzen, H. Ma, H. Deng, A. Witecka, S. B. Andersen, J. Drozak, H. Guo, P. Qian, H. Li, J. Mecinovic

This study investigates the substrate specificity of human SETD3, showing it can methylate histidine and its mimics, with histidine being the most efficient substrate.

bioRxiv · Dec 30, 2021 · PreprintBiochemistry

The Mammalian Cytosolic Type 2 (R)-β-hydroxybutyrate Dehydrogenase (BDH2) is 4-oxo-L-proline Reductase (EC1.1.1.104)

S. P. Kwiatkowski, M. Bozko, M. Zarod, A. Witecka, A. K. Jagielski, J. Drozak

This paper identifies BDH2 as the enzyme responsible for reducing 4-oxo-L-proline to cis-4-hydroxy-L-proline, challenging the previous belief that it produces trans-4-hydroxy-L-proline.

bioRxiv · Feb 23, 2021 · PreprintBiochemistry

Structural insights into SETD3-mediated histidine methylation on β-actin

Q. Guo, S. Liao, S. Kwiatkowski, W. Tomaka, H. Yu, G. Wu, X. Tu, J. Min, J. Drozak, C. Xu

This study presents two structures of SETD3 bound to β-actin peptides, revealing sequence-specific recognition and methylation mechanism.

bioRxiv · Feb 13, 2019Biochemistry

SETD3 protein is the actin-specific histidine N-methyltransferase

S. Kwiatkowski, A. K. Seliga, M. Veiga-da-Cunha, D. Vertommen, M. Terreri, T. Ishikawa, I. Grabowska, A. K. Jagielski, J. Drozak

This study identifies SETD3 as the actin-specific histidine N-methyltransferase in vertebrates, showing it methylates β-actin at H73 and affects actin dynamics and glycolytic activity.

bioRxiv · Feb 20, 2018Biochemistry