Structure elucidation of colibactin.
M. Xue, C. S. Kim, A. R. Healy, K. W. Wernke, Z. Wang, M. C. Frischling, E. E. Shine, W. Wang, S. B. Herzon, J. M. Crawford
This study determines the structure of colibactin using genetics, isotope labeling, tandem MS, and chemical synthesis, confirming its role in DNA cross-linking and colorectal cancer.
bioRxiv · Mar 12, 2019 · PreprintMicrobiology