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2 papers
Recent·Most cited
M. Xue, C. S. Kim, A. R. Healy, K. W. Wernke, Z. Wang, M. C. Frischling, E. E. Shine, W. Wang, S. B. Herzon, J. M. Crawford
This study determines the structure of colibactin using genetics, isotope labeling, tandem MS, and chemical synthesis, confirming its role in DNA cross-linking and colorectal cancer.
bioRxiv · Mar 12, 2019 · PreprintMicrobiology
E. E. Shine, M. Xue, J. R. Patel, A. R. Healy, Y. V. Surovtseva, S. Herzon, J. M. Crawford
This study shows that free model colibactins induce DNA double-strand breaks in human cells without requiring host bacteria, revealing mechanisms of genotoxicity and product diversification in colibactin biosynthesis.
bioRxiv · Sep 29, 2018Cancer Biology