Discovery of an IKK2 Site that Allosterically Controls Its Activation
S. J. Hotchkiss, M. C. Mulero, G. J. Chan, T. Biswas, S. Polley, C. Ohn, S. Konduri, O. Demir, R. E. Amaro, G. Ghosh
This paper identifies a novel allosteric site on IKK2 that can be targeted by small-molecule inhibitors to block its activity without ATP-competitive off-target effects.
bioRxiv · Jan 27, 2021 · PreprintBiochemistry