T. Biswas

Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

This study identifies dual-specific autophosphorylation in IKK2, showing tyrosine autophosphorylation and ATP-contacting residue K44 regulate substrate specificity for IκBα phosphorylation during NF-κB activation.

Potential role of microRNAs in regulating transcriptional profile, and sculpting development and metabolism in cavefish.

This study identifies 683 miRNAs in cavefish, revealing their role in regulating development and metabolism through differential expression and pathway involvement.

3D spheroid culturing of Astyanax mexicanus liver-derived cell lines recapitulates distinct transcriptomic and metabolic states of in vivo tissue environment.

This study uses 3D spheroid culturing to model metabolic and transcriptomic states of Astyanax mexicanus liver cells, revealing cave-specific metabolic signatures.

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntingtons disease

This study shows that F2,6BP restores PNKP activity and alleviates neurodegenerative symptoms in HD and SCA3 by rescuing DNA repair and genome integrity.

Structural Requirements for Reverse Transcription by a Diversity-generating Retroelement

This study identifies how surrounding RNA structures facilitate reverse transcription in DGRs by positioning an RNA homoduplex for cis-priming and regulating mutagenesis.

Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer.

This paper shows that inhibiting MALAT1 increases sensitivity to PARP inhibitors in prostate cancer by impairing homologous recombination.

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code

The paper investigates how a three-dimensional pre-mRNA structural scaffold influences spliceosomal component recruitment beyond traditional splice signals.

Discovery of an IKK2 Site that Allosterically Controls Its Activation

This paper identifies a novel allosteric site on IKK2 that can be targeted by small-molecule inhibitors to block its activity without ATP-competitive off-target effects.

Structural disruption of exonic stem-loops immediately upstream of the intron regulates mammalian splicing

The paper shows that exonic stem-loops upstream of introns regulate splicing by modulating splicing factor accessibility.

Spring-loaded inverted pendulum goes through two contraction-extension cycles during the single stance phase of walking

The paper shows that the spring-loaded inverted pendulum (SLIP) can model the single stance phase of walking but has limitations, leading to the development of a new model, ARSLIP, which accounts for active elements and contraction-extension cycles in the leg spring.