Author

M. Alifano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Damotte· 2 shared E. Donnadieu· 2 shared L. Vimeux· 2 shared M. Calcagnile· 2 shared P. Alifano· 2 shared P. Forgez· 2 shared A. Iannelli· 1 shared A. Kaiser· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

D. Damotte

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mitochondrial metabolism sustains CD8+ T cellmigration for an efficient infiltration into solid tumors

L. Simula, M. Fumagalli, L. Vimeux, I. Rajnpreht, P. Icard, D. An, F. Pendino, D. Damotte, A. Lupo-Mansuet, M. Alifano, M.-C. Alves-Guerra, E. Donnadieu

This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.

bioRxiv · Jan 12, 2024Immunology

The lethal triad: SARS-CoV-2 Spike, ACE2 and TMPRSS2. Mutations in host and pathogen may affect the course of pandemic.

M. Calcagnile, P. Forgez, P. Alifano, M. Alifano

This study uses in silico methods to show how mutations in SARS-CoV-2 Spike protein affect interactions with ACE2 and TMPRSS2, and how host genetic variation influences these interactions.

bioRxiv · Jan 12, 2021 · PreprintMicrobiology

CAR T cell entry into tumor islets is a two-step process dependent on IFNγ and ICAM-1

C. Kantari-Mimoun, S. Barrin, S. Haghiri, C. Gervais, J. Mittelstaet, N. Mockel-Tenbrinck, A. Kinkhabwala, D. Damotte, A. Lupo, M. Sibony, M. Alifano, L. Vimeux, E. Dondi, N. Bercovici, A. Trautmann, , E. Donnadieu

This study shows CAR T cell entry into tumor islets occurs in two steps, requiring IFNγ and ICAM-1 for effective infiltration.

bioRxiv · May 27, 2020Immunology

ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study

M. Calcagnile, P. Forgez, A. Iannelli, C. Bucci, M. Alifano, P. Alifano

This study uses in silico analysis to show that ACE2 SNPs S19P and K26R may affect SARS-CoV-2 spike binding, with S19P potentially offering protection and K26R possibly increasing disease severity.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology