The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours
C. Prieto-Garcia, O. Hartmann, M. Reissland, F. Braun, T. Fischer, S. Walz, A. Fischer, M. Calzado, A. Orian, M. Rosenfeldt, M. Eilers, M. E. Diefenbacher
This study identifies USP28 as a stabilizer of {Delta}Np63 in squamous cell carcinomas, showing that inhibiting USP28 reduces tumor growth and survival.
bioRxiv · Jun 27, 2019Cancer Biology