Biosynthetic heme of malaria parasite induces cerebral pathogenesis by regulating hemozoin formation and griseofulvin can prevent cerebral malaria
M. Chandana, A. Anand, S. Ghosh, S. Beura, S. Jena, A. R. Suryawanshi, G. Padmanaban, V. Arun Nagaraj
The paper shows biosynthetic heme in malaria parasites promotes cerebral pathogenesis by enhancing hemozoin formation, and griseofulvin prevents cerebral malaria by targeting heme synthesis.
bioRxiv · Apr 27, 2021 · PreprintMicrobiology