Maturation signatures of conventional dendritic cell subtypes in COVID-19 reflect direct viral sensing
L. Marongiu, G. Protti, F. A. Facchini, M. Valache, F. Mingozzi, V. Ranzani, A. R. Putignano, L. Salviati, V. Bevilacqua, S. Curti, M. Crosti, M. D'Angio, L. R. Bettini, A. Biondi, L. Nespoli, , F. Granucci
This study identifies maturation signatures of conventional dendritic cell subtypes in COVID-19, showing that cDC2s exhibit viral sensing and inflammatory activation while losing antigen presentation capacity, correlating with disease severity.
bioRxiv · Mar 3, 2021Immunology