A protective role for B-1 cells and oxidation-specific epitope IgM in lung fibrosis
J. M. Sturek, R. T. Hannan, A. Upadhye, E. Otoupalova, E. T. Faron, A. A. E. Atya, C. Thomas, V. Johnson, A. Miller, J. C. Garmey, M. D. Burdick, T. H. Barker, A. Kadl, Y. M. Shim, C. A. McNamara
This study shows B-1 cells and IgMOSE reduce lung fibrosis by modulating CXCR4 and Id3, with sIgM-/- mice showing increased mortality from bleomycin injury.
bioRxiv · Apr 11, 2024 · PreprintImmunology