Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localised in the Polymerase (3Dpol) Encoding Region.
L. Lasecka-Dykes, F. Tulloch, P. Simmonds, G. A. Luke, P. Ribeca, S. Gold, N. J. Knowles, C. F. Wright, J. Wadsworth, M. Azhar, D. P. King, T. J. Tuthill, T. Jackson, M. D. Ryan
The paper identifies three critical RNA structures in the FMDV genome essential for replicon replication, while 42 others are non-essential, suggesting potential targets for vaccine development.
bioRxiv · Jan 4, 2021Evolutionary Biology