T. J. Tuthill

Membrane interactions and uncoating of Aichi virus, a picornavirus that lacks a VP4

This study investigates the role of VP0 in Aichi virus membrane interactions and uncoating, showing that pH affects genome exposure and pore formation analogous to VP4 in other picornaviruses.

Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localised in the Polymerase (3Dpol) Encoding Region.

The paper identifies three critical RNA structures in the FMDV genome essential for replicon replication, while 42 others are non-essential, suggesting potential targets for vaccine development.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

Detection of antibodies against a conserved capsid epitope as the basis of a novel universal serological test for foot-and-mouth disease

This paper identifies a conserved epitope in FMDV capsid protein VP2 and develops a universal ELISA to detect antibodies against all FMDV strains with high sensitivity and specificity.