Short-course but not prolonged treatment with ATR inhibitor AZD6738 integrates with radiotherapy to generate a tumor antigen-specific CD8+ T cell expansion in the periphery
F. P. Vendetti, D. A. Clump, S. Schamus-Haynes, M. DiMayorca, N. Islam, J. Chang, J. H. Beumer, C. J. Bakkenist
The paper shows that short-course ATR inhibitor treatment with radiotherapy enhances CD8+ T cell expansion in draining lymph nodes, while prolonged treatment inhibits this effect.
bioRxiv · Apr 11, 2022 · PreprintCancer Biology