Bma-LAD-2, an intestinal cell adhesion protein, as a potential therapeutic target for lymphatic filariasis
A. F. Flynn, R. T. Taylor, M. E. Pazgier, S. Bennuru, A. R. Lindrose, S. L. Sterling, C. P. Morris, T. K. Maugel, T. B. Nutman, E. Mitre
This study identifies Bma-LAD-2 as an essential protein in adult Brugia malayi worms, showing that its knockdown reduces worm motility, fecundity, and viability, suggesting it as a potential therapeutic target for lymphatic filariasis.
bioRxiv · Sep 9, 2021 · PreprintMicrobiology