Membrane domains and phosphatase exclusion produce robust signaling responses in B cells engaged with natural ligands and artificial cross-linkers presented on lipid bilayers.
M. F. Nunez, K. Wisser, S. Veatch
This study shows that B cells form robust phase-like domains when engaging with natural ligands or cross-linkers on lipid bilayers, integrating membrane organization and phosphatase exclusion to enhance signaling.
bioRxiv · May 29, 2019 · PreprintBiophysics