Modulation of calcium signaling on demand to decipher the molecular mechanisms of primary aldosteronism
B. Fedlaoui, T. Cosentino, Z. R. Al Sayed, I. Giscos-Douriez, N. Faedda, M. Fayad, J.-S. Hulot, C. Magnus, S. M. Sternson, S. Travers-Allard, S. Baron, F. L. Fernandes-Rosa, M.-C. Zennaro, S. Boulkroun
This study establishes an adrenocortical cell model to modulate sodium entry and calcium signaling, revealing its role in aldosterone biosynthesis and PA development.
bioRxiv · Apr 29, 2024Physiology