Characterization of Reactive Oxygen Species Signaling changes in a cell culture model of skeletal muscle ageing, and its application to screening pharmacokinetically-relevant exposures of dietary polyphenols for bioactivity.
N. Hayes, M. Fogarty, L. Sadofsky, H. S. Jones
This paper characterizes RONS signaling changes in aged skeletal muscle cells and identifies kaempferol and resveratrol as polyphenols that reduce multiple RONS markers in aged C2C12 cells.
bioRxiv · Nov 20, 2021 · PreprintPharmacology & Toxicology