Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species
K. Lanko, L. Sun, M. Froeyen, P. Leyssen, L. Delang, C. Mirabelli, J. Neyts
The paper identifies mutations in picornaviruses that confer resistance to vapendavir, including both pocket and non-pocket mutations, and shows some mutations require drug presence for viral replication.
bioRxiv · Jul 16, 2020Microbiology