Quantifying signal persistence in the T cell signaling network using an optically controllable antigen receptor
M. J. Harris, M. Fuyal, J. R. James
The paper quantifies T cell signaling persistence using an optically controllable antigen receptor and finds that signals dissipate rapidly, requiring sustained input for gene transcription and enabling enhanced T cell activation through pulsatile stimulation.
bioRxiv · Oct 30, 2020Biochemistry