Pervasive Transcriptome Interactions of Protein-Targeted Drugs
L. Fang, W. A. Velema, Y. Lee, L. Xiao, M. G. Mohsen, A. M. Kietrys, E. T. Kool
This study develops a method to assess RNA off-target interactions of protein-targeted drugs and finds they pervasively affect the transcriptome, potentially causing toxicity.
bioRxiv · Jul 18, 2022 · PreprintPharmacology & Toxicology