Facile method for screening clinical T cell receptors for off-target peptide-HLA reactivity
M. H. Gee, X. Yang, K. C. Garcia
The paper develops a yeast-display platform to screen TCRs for off-target peptide-HLA reactivity, identifying clinical toxicity associated with an affinity-matured TCR.
bioRxiv · Nov 22, 2018 · PreprintImmunology