Selection of a Promiscuous Minimalist cAMP Phosphodiesterase from a Library of De Novo Designed Proteins
J. D. Schnettler, M. S. Wang, M. Gantz, C. Karas, M. H. Hecht, F. Hollfelder
The paper screens a library of de novo designed proteins to identify a promiscuous cAMP phosphodiesterase, finding that truncation and structural dynamics enable catalytic activity.
bioRxiv · Feb 13, 2023Biochemistry